BDBM21690 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid::1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid::Bay 09867::CHEMBL8::Ciprinol::Cipro::Ciprofloxacin::US11590142, Compound Ciprofloxacin::US9138393, Ciprofloxacin HCl::US9144538, Ciprofloxacin HCl

SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O

InChI Key InChIKey=MYSWGUAQZAJSOK-UHFFFAOYSA-N

Data  2 KI  105 IC50  1 Kd  1 EC50

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 21690   

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of topoisomerase 4 decatenation in Staphylococcus aureus ATCC 29213More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of supercoiling activity of topoisomerase IV from Staphylococcus aureus ISP 794; Range = 2.5-5 ug/mLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank